![]() In this way it might become possible to apply the results of animal research and indicate the most effective method of treatment. With improved methods of resuscitation it is to be hoped that the mortality rate will be reduced and that such data will become available. ![]() Due to the suddeness of the catastrophe and the very high mortality, haemodynamic data in humans is virtually non-existent. Further work is required to elucidate the relative contributions of these various factors. Purpose: Amniotic fluid embolism (AFE) is a leading cause of obstetrical cardiac arrest and maternal morbidity. Embolism, Amniotic Fluid / diagnosis Embolism, Amniotic Fluid / epidemiology Embolism, Amniotic Fluid / etiology Female Humans Population Surveillance / methods Pregnancy United Kingdom / epidemiology. The principal factors that have been implicated in the clinical syndrome of amniotic fluid embolism are anaphylaxis, vascular obstruction by particulate matter, vascular spasm due to prostaglandins and possibly some other vasoactive substances, and the possibility that all the changes could be explained by disseminated intravascular coagulation as a primary event. Lung scanning is a useful aid to diagnosis. ![]() Attempts should be made to secure a definitive diagnosis in life by examination of blood obtained from the right side of the heart and the sputum for elements of amniotic fluid. Objective: To test whether serum insulin-like growth factor binding protein-1 could be used as a biomarker of amniotic fluid passage into the maternal circulation. It must be suspected in any patient who collapses or bleeds excessively during labour or the immediate post-partum period. The statement that amniotic fluid embolism is the most dangerous and untreatable condition in obstetrics appears to be true.
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